Association Between Activation of a Rapid Response Team and Outcomes of Sepsis in General Wards: A Nationwide Observational Study Using the Japanese Intensive Care Patient Database
Primary resultResult — go to the resultRisk difference 1.4% 95% CI −2.8% to 5.6%Authors' conclusion
In this nationwide study of septic patients requiring ICU admission, RRT activation was not associated with improvement of in-hospital mortality or other clinical outcomes.
Study context
- Population
- Adults admitted to the ICU with sepsis or septic shock after initial management in a general ward, Japanese Intensive Care PAtient Database (JIPAD), fiscal years 2017–2022
- Participants
- 3,883 adults · 95 ICUs
- Comparison
- Rapid response team (RRT) activation before ICU admission vs no RRT activation
- RRTn = 850
- Controln = 3,033reference
- Primary endpoint
- In-hospital mortality
Methodological detailsobservational cohort study, nationwide, stabilized inverse probability of treatment weighting, generalized estimating equations (clustering at hospital level)
- Observational cohort study
- Nationwide
- Stabilized inverse probability of treatment weighting
- Generalized estimating equations (clustering at hospital level)
Primary result
As reported in the abstract
Risk difference
1.4%
95% CI −2.8% to 5.6%
P = 0.51
By group
RRT vs Control
risk difference 1.4% (95% CI −2.8% to 5.6%); P = 0.51
Secondary outcomes
Discharge to home, ICU mortality, hospital LOS, ICU LOS
- No significant differences
Original publication
Association Between Activation of a Rapid Response Team and Outcomes of Sepsis in General Wards: A Nationwide Observational Study Using the Japanese Intensive Care Patient Database. Crit Care Med. Published 12 September 2025. doi:10.
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