Remote Monitoring Approaches to Reduce Readmissions After Infection and Sepsis: A Randomized Clinical Trial
An erratum to this article was published (JAMA Netw Open, 1 Oct 2026 ↗)
Authors' conclusion
Among trial patients discharged after hospitalization for serious infections, remote monitoring did not increase time spent alive at home but reduced it in those 65 years and older.
Study context
- Population
- Postdischarge patients ≥21 years with sepsis or lower respiratory tract infection at moderate or high readmission risk, western Pennsylvania, UPMC Health Plan or fee-for-service Medicare, with internet-connected device, no cognitive impairmentincluded in analysis
- Participants
- 1,286 patients
- Comparison
- Four remote monitoring strategies vs usual care
- Usual caren = 399reference
- Remote patient monitoring (RPM)-low standard responsen = 204
- RPM-high standard responsen = 129
- RPM-low enhanced responsen = 383
- RPM-high enhanced responsen = 171
- Primary endpoint
- Days at home (cumulative odds ratios vs usual care, posterior probability)
- Follow-up
- 90 days after discharge
Methodological detailsresponse adaptive randomization, multicentre (19 hospitals), Bayesian analysis, 529 of 887 (59.6%) assigned to remote monitoring enrolled in the program
- Response adaptive randomization
- Multicentre (19 hospitals)
- Bayesian analysis
- 529 of 887 (59.6%) assigned to remote monitoring enrolled in the program
Primary result
As reported in the abstract
Days at home · 90 days
COR
- RPM-low standard response
- 0.96 (95% CrI 0.70–1.32)
- RPM-high standard response
- 0.86 (95% CrI 0.60–1.23)
- RPM-low enhanced response
- 1.01 (95% CrI 0.76–1.33)
- RPM-high enhanced response
- 0.96 (95% CrI 0.69–1.36)
Secondary outcomes
| Outcome | Values | COR (95% CrI) |
|---|---|---|
| At least 1 readmission | Usual care 37.8% · RPM-low standard response 39.7% · RPM-high standard response 44.2% · RPM-low enhanced response 37.3% · RPM-high enhanced response 36.3% | |
| Days at home, patients ≥65 years (subgroup) · 90 daysStandard response vs Usual care · inferiority probability 99.6% · CrI | 0.56 (0.36–0.85) | |
| Days at home, patients ≥65 years (subgroup) · 90 daysEnhanced response vs Usual care · inferiority probability 97.9% · CrI | 0.67 (0.45–0.98) |
Days at home, patients ≥65 years (subgroup) · 90 days
- Fewer home days vs usual care
Original publication
Remote Monitoring Approaches to Reduce Readmissions After Infection and Sepsis: A Randomized Clinical Trial. JAMA Netw Open. Published 1 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →