Respiratory failure & ventilation
Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome
Authors' conclusion
There was a nonlinear relationship between age and mortality in pediatric and adult ARDS.
Study context
- Population
- Children and adults with acute respiratory distress syndrome (ARDS) meeting Berlin criteria43% moderate ARDS
- Participants
- 7,862 children
- Exposure
- Age across pediatric and adult ARDS
- Pediatric cohortsn = 1,236
- Adult trialsn = 5,547
- Adult observationaln = 1,079
- Outcome
- Association between age and mortality
- Follow-up
- 90 days
Methodological detailspooled pediatric and adult cohorts and trials, fractional polynomial logistic regression, adjusted
- Pooled pediatric and adult cohorts and trials
- Fractional polynomial logistic regression
- Adjusted
Main finding
As reported in the abstract
Age–mortality relationship
- Nonlinear relationship between age and mortality: risk increased at an accelerating rate between 11 and 65 years of age, more slowly thereafter
- Adjusted for sex, PaO2/FiO2, immunosuppressed status, year of study, and observational vs RCT; each study a fixed effect
Observational data: associations, not effects.
Further findings
90-day mortality by cohort
Original publication
Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. Published 1 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →