Respiratory failure & ventilation
Rapidly improving ARDS differs clinically and biologically from persistent ARDS
Authors' conclusion
This study identifies a high prevalence of RIARDS in a multicenter observational cohort and confirms the more benign clinical course of these patients.
Study context
- Population
- Endotracheally intubated patients meeting Berlin criteria for ARDS at a tertiary care centre and an urban safety net hospital
- Participants
- 215 participants
- Exposure
- Rapidly improving acute respiratory distress syndrome (RIARDS) vs persistent ARDS
- Outcome
- Clinical and biological features of RIARDS and its association with inflammatory subphenotypes
Methodological detailstwo sites
- Two sites
Main finding
As reported in the abstract
Prevalence of RIARDS
RIARDS
21%
Observational data: associations, not effects.
Further findings
Hospital mortality
P < 0.001
Hypoinflammatory phenotype
P = 0.001
Median
| Outcome | RIARDS | Persistent ARDS | P value |
|---|---|---|---|
| ICU-free days | 24 | 0 | P < 0.001 |
Plasma IL-6, IL-8 and PAI-1 · day of enrollment
- Significantly lower in RIARDS
Original publication
Rapidly improving ARDS differs clinically and biologically from persistent ARDS. Crit Care. Published 22 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →