Respiratory failure & ventilation
The Predictive Validity of the Berlin Definition of Acute Respiratory Distress Syndrome for Patients With COVID-19-Related Respiratory Failure Treated With High-Flow Nasal Oxygen: A Multicenter, Prospective Cohort Study*
Authors' conclusion
The predictive validity of the Berlin ARDS definition was similar for HFNO-treated patients as compared with the original population of invasively ventilated patients.
Study context
- Population
- High-flow nasal oxygen (HFNO)-treated adults (>18 years) with confirmed COVID-19-related acute respiratory failure meeting acute respiratory distress syndrome (ARDS) criteria (PaO2/FiO2 <300 mm Hg, bilateral infiltrates, worsening symptoms <1 week); 5 ICUs in Argentina, March 2020–September 20211,231 screened
- Participants
- 696 adults
- Exposure
- Mild vs Moderate vs Severe
- Mildn = 30
- Moderaten = 380
- Severen = 286
- Outcome
- Predictive validity of the Berlin definition for mortality (AUC)
- Follow-up
- Day 28
Methodological detailsmulticentre, consecutive inclusion
- Multicentre
- Consecutive inclusion
Main finding
As reported in the abstract
Predictive validity for mortality (AUC), study cohort
AUC
0.606
95% CI 0.561–0.651
Observational data: associations, not effects.
Further findings
Predictive validity across subgroups (subgroup) · day 28
- AUC for subgroups similar to that of the overall cohort
Received invasive mechanical ventilation (IMV)
- Patients receiving IMV
- 256 (37%)
Mortality · day 28
- Died
- 142 (21%)
- Deaths with severe ARDS
- 81 (57%)
- Mortality occurred primarily in patients transitioned to IMV
Original publication
The Predictive Validity of the Berlin Definition of Acute Respiratory Distress Syndrome for Patients With COVID-19-Related Respiratory Failure Treated With High-Flow Nasal Oxygen: A Multicenter, Prospective Cohort Study*. Crit Care Med. Published 16 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →