Respiratory failure & ventilation
Broadening the Berlin definition of acute respiratory distress syndrome (ARDS) to patients receiving high-flow nasal oxygen: an observational study in patients with acute hypoxemic respiratory failure due to COVID-19
Authors' conclusion
Using a broadened definition of ARDS may facilitate an earlier diagnosis of ARDS in patients receiving HFNO; however, ARDS patients receiving HFNO and ARDS patients receiving ventilation have distinct baseline characteristics and mortality rates.
Study context
- Population
- Critically ill adults with acute hypoxemic respiratory failure due to COVID-19
- Participants
- 728 adults
- Exposure
- High-flow nasal oxygen (HFNO) vs Ventilation
- HFNOn = 229
- Ventilationn = 499reference
- Outcome
- ICU mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
P = 0.001
Observational data: associations, not effects.
Secondary outcomes
ICU mortality by PaO2/FiO2 category (mild, moderate, severe), HFNO (subgroup) — Mild vs Moderate vs Severe · across categories
P = 0.906
ICU mortality by PaO2/FiO2 category (mild, moderate, severe), ventilation (subgroup) — Mild vs Moderate vs Severe · across categories
P = 0.002
Baseline severity
- HFNO had lower disease severity scores and lower PaO2/FiO2 than ventilation
Original publication
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