Respiratory failure & ventilation
Epidemiology, Ventilatory Patterns, and Outcomes in Acute Hypoxemic Respiratory Failure Among ICU Patients Requiring Respiratory Support: A Registry-Based Cohort Study
Authors' conclusion
AHRF is common early after ICU admission among patients requiring supplemental oxygen or respiratory support and is frequently managed using ARDS-based strategies.
Study context
- Population
- Adult ICU patients receiving supplemental oxygen or respiratory support meeting acute hypoxemic respiratory failure (AHRF) criteria (PaO2/FiO2 ≤300 mm Hg or SpO2/FiO2 ≤315) within the first 24 h of ICU admission; 9 University of Toronto-affiliated ICUs, 2014–2023recorded in the registry
- Participants
- 21,714 patients
- Outcome
- AHRF prevalence
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Met AHRF criteria
10,832
50%
Observational data: associations, not effects.
Secondary outcomes
Invasive mechanical ventilation (IMV) among AHRF patients
- Required IMV
- 76%
- Most received lung-protective ventilation
ICU LOS, IMV duration, ventilator-free days, ICU discharge at 30 days, by AHRF severity
- With increasing AHRF severity, ICU LOS and IMV duration increased; ventilator-free days and probability of ICU discharge at 30 days decreased
ICU mortality
- Overall
- 23%
- Patients on IMV with severe AHRF
- 47%
Original publication
Epidemiology, Ventilatory Patterns, and Outcomes in Acute Hypoxemic Respiratory Failure Among ICU Patients Requiring Respiratory Support: A Registry-Based Cohort Study. Crit Care Med. Published 12 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →