Respiratory failure & ventilation
Effects of High-Flow Nasal Cannula and Helmet Continuous Positive Airway Pressure in Acute Hypoxemic Respiratory Failure
Authors' conclusion
In patients with mild and moderate AHRF, HFNC and helmet CPAP ameliorated minute ventilation and respiratory rate, reduced inspiratory effort, and increased oxygenation compared with COT; the application of 10 cm H 2 O of PEEP during CPAP support worsened mechanical power.
Study context
- Population
- Adults with acute hypoxemic respiratory failure (AHRF) (PaO2 <60 mm Hg or PaO2/FiO2 <300 with positive end-expiratory pressure (PEEP) ≥5 cm H 2 O, PaCO2 <45 mm Hg), general surgical-medical ICU, Milan, Italycrossover
- Participants
- 33 adults
- Comparison
- High-flow nasal cannula (HFNC) and helmet continuous positive airway pressure (CPAP) vs conventional oxygen therapy (COT)
Methodological detailsrandom order, single-centre
- Random order
- Single-centre
Primary result
As reported in the abstract
Minute ventilation, mean ± SD (HFNC, CPAP 5, CPAP 10 vs COT), L/min
9.2 ± 3.2, 8.8 ± 2.3, and 9.3 ± 2.7 vs. 10.9 ± 3.3
p < 0.001
ΔPes (HFNC, CPAP 5, CPAP 10 vs COT), cm H 2 O
−6.0 [−7.8 to −4.0], −5.8 [−7.2 to −4.5], and −5.9 [−8.0 to −4.0] vs. −7.5 [−10.8 to −6.5]
p < 0.001
PaO2/FiO2, mean ± SD (HFNC, CPAP 5, CPAP 10 vs COT)
188 ± 57, 208 ± 62, and 213 ± 69 vs. 129 ± 32
p < 0.001
Original publication
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