Respiratory failure & ventilation
Comparison of Noninvasive Mechanical Ventilation With High-Flow Nasal Cannula, Face-Mask, and Helmet in Hypoxemic Respiratory Failure in Patients With COVID-19: A Randomized Controlled Trial*
- stopped prematurely
- Trial stopped prematurely because of a decline in cases
Authors' conclusion
This exploratory trial found no difference in intubation rate and mortality among the three intervention groups for the COVID-19 patients with hypoxemic respiratory failure
Study context
- Population
- Adults with COVID-19 and PaO2/FiO2 <300, three tertiary centres in Oman, Feb–Aug 2021151 analysed
- Participants
- 159 adults
- Comparison
- High-flow nasal cannula (HFNC) vs helmet continuous positive airway pressure (CPAP) vs face-mask CPAP
- HFNCn = 47
- Helmet CPAPn = 52
- Face-mask CPAPn = 52reference
- Primary endpoint
- Endotracheal intubation rate
Methodological detailsopen-label, parallel, permuted block randomization, multicentre
- Open-label
- Parallel
- Permuted block randomization
- Multicentre
Primary result
As reported in the abstract
Endotracheal intubation
Each group vs face-mask CPAPRelative risk (95% CI)
HFNC
0.97(0.63–1.49)
Helmet CPAP
1.0(0.66–1.51)
Secondary outcomes
Time to intubation
Mortality · 28 days
Mortality · 90 days
- Time to intubation: p = 0.11
- Mortality: p = 0.24
- Mortality: p = 0.89
Original publication
Comparison of Noninvasive Mechanical Ventilation With High-Flow Nasal Cannula, Face-Mask, and Helmet in Hypoxemic Respiratory Failure in Patients With COVID-19: A Randomized Controlled Trial*. Crit Care Med. Published 13 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →