ICU sedation, delirium & recovery
The association between albumin-corrected anion gap and in-hospital mortality in critically ill chronic obstructive pulmonary disease (COPD) patients: A multicenter retrospective study from eICU collaborative research database
Authors' conclusion
ACAG is an effective predictor of in-hospital mortality in ICU patients with COPD, offering better predictive power than the anion gap.
Study context
- Population
- Intensive care unit (ICU)-admitted patients with COPD, eICU Database
- Participants
- 4,304 patients
- Exposure
- Albumin-corrected anion gap (ACAG) quartiles; ACAG vs anion gap for prediction
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, eICU Collaborative Research Database
- Multicentre
- eICU Collaborative Research Database
Main finding
As reported in the abstract
- Higher ACAG levels a strong predictor of in-hospital mortality
- Non-linear relationship; sharp increase in mortality risk when ACAG exceeded 15
Observational data: associations, not effects.
Further findings
Predictive performance, ACAG vs anion gap (ROC, decision curve analysis (DCA))
- ACAG superior predictive ability vs anion gap
In-hospital mortality by age (subgroup)
- Stronger predictive value of ACAG in patients younger than 65 years
Original publication
The association between albumin-corrected anion gap and in-hospital mortality in critically ill COPD patients: A multicenter retrospective study from eICU collaborative research database. J Crit Care. Published 16 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →