Association Between Antibiotic Redosing Before Incision and Risk of Incisional Site Infection in Children With Appendicitis
Main findingResult — go to the resultOdds ratio 0.84 95% CI 0.39–1.83Authors' conclusion
Redosing of antibiotics within 1 hour of incision in children who received their initial dose within 6 hours of incision was not associated with reduction in risk of incisional site infection unless cefoxitin was used as the initial antibiotic.
Study context
- Population
- Children undergoing appendectomy at 14 Eastern Pediatric Surgery Network hospitals (July 2016–June 2020) who received antibiotics at diagnosis 1–6 hours before incision
- Participants
- 3,533 children · 14 hospitals
- Exposure
- Antibiotic redosing within 1 hour of incision vs no redosing
- Outcome
- Incisional surgical site infection (iSSI)
Methodological detailsmulticentre, multivariable logistic regression
- Multicentre
- Multivariable logistic regression
Main finding
As reported in the abstract
Odds ratio
0.84
95% CI 0.39–1.83
By group
Redosed vs Non-redosed
OR 0.84 (95% CI 0.39–1.83)
Observational data: associations, not effects.
Further findings
| Outcome | Redosed | Non-redosed | OR (95% CI) | |
|---|---|---|---|---|
| iSSI, cefoxitin as initial antibiotic (subgroup) | 1.0% | 2.5% | 0.38 (0.17–0.84) | |
| 0.10.31310Odds ratio (log scale) |
Incisional surgical site infection (iSSI), other subgroups (subgroup)
- No benefit with other antibiotic regimens, longer time from initial antibiotic to incision, or greater disease severity
Original publication
Association Between Antibiotic Redosing Before Incision and Risk of Incisional Site Infection in Children With Appendicitis. Ann Surg. Published 1 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →