Pediatric anesthesia & critical care
Delays to Antibiotics in the Emergency Department and Risk of Mortality in Children With Sepsis
An erratum to this article was published (JAMA Netw Open, 2 Dec 2024 ↗)
Main finding · Sepsis-attributable 3-day mortalityResult — go to the resultAdjusted odds ratio 3.44 95% CI 1.20–9.93Authors' conclusion
In this cohort of pediatric patients with sepsis, 3-day and 30-day sepsis-attributable mortality increased with delays in antibiotic administration 330 minutes or longer from emergency department arrival.
Study context
- Population
- Patients aged 29 days to <18 years with sepsis recognised within 1 hour of ED arrival, 51 US children's hospitals (Improving Pediatric Sepsis Outcomes collaborative), 2017–2021
- Participants
- 19,515 cases
- Exposure
- Antibiotic administration ≥330 vs <330 minutes from ED arrival
- <330 minutesn = 19,164reference
- ≥330 minutesn = 351
- Outcome
- Sepsis-attributable 3-day mortality
- Follow-up
- 3 days
Methodological detailsmulticentre, piecewise regression, adjusted logistic regression
- Multicentre
- Piecewise regression
- Adjusted logistic regression
Main finding
As reported in the abstract
Adjusted odds ratio
3.44
95% CI 1.20–9.93
P = 0.02
Events by group
≥330 minutes vs <330 minutes
aOR 3.44 (95% CI 1.20–9.93); P = 0.02
- Estimated time to antibiotic administration at which 3-day sepsis-attributable mortality increased (inflection point)
- 330 minutes
Observational data: associations, not effects.
Secondary outcomes
| Outcome | <330 minutes | ≥330 minutes | aOR (95% CI) | P value | |
|---|---|---|---|---|---|
| Sepsis-attributable 30-day mortality | 0.9% | 2.0% | 3.63 (1.59–8.30) | P = 0.002 | |
| 0.10.31310Adjusted odds ratio (log scale) |
Time to antibiotic administration (all cases)
- Median (IQR) time to antibiotic administration
- 69 (47-116) minutes
Original publication
Delays to Antibiotics in the Emergency Department and Risk of Mortality in Children With Sepsis. JAMA Netw Open. Published 3 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →