Association Between Arterial Hyperoxia and Mortality in Pediatric and Adult Patients Undergoing Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis
Authors' conclusion
In critically ill patients on VV- or VA-ECMO, increased Pa o2 values were associated with increased 28-day mortality in ECMO patients.
Study context
- Population
- Pediatric and adult patients receiving VV-ECMO, venoarterial ECMO (VA-ECMO) or extracorporeal cardiopulmonary resuscitation (ECPR)
- Participants
- 17,766 participants · 13 cohort studies
- Comparison
- Elevated PaO2 vs normoxia
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsrandom-effects model, PRISMA 2020
- Random-effects model
- PRISMA 2020
Pooled result
As reported in the abstract
28-day mortality by PaO2 threshold
Each group vs normoxiaOdds ratio (95% CI)P value
Hyperoxia (≥300 mm Hg)
1.56(1.31–1.85)
P < 0.01Hyperoxia (≥200 mm Hg)
1.43(1.10–1.87)
P < 0.01Hyperoxia (≥150 mm Hg)
1.51(1.15–1.98)
P < 0.01Hyperoxia (≥100 mm Hg)
1.44(1.03–2.02)
P = 0.03Further pooled results
Mortality, studies reporting adjusted OR (sensitivity analysis)
- Similar results
Mortality in adult and pediatric populations (subgroup)
- Association observed in both adult and pediatric populations
Original publication
Association Between Arterial Hyperoxia and Mortality in Pediatric and Adult Patients Undergoing Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis. Anesth Analg. Published 20 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →