Long-Term Mortality and Functional Outcomes After Extracorporeal Membrane Oxygenation in Critically Ill Adults: A Systematic Review and Meta-Analysis
Authors' conclusion
Long-term mortality following ECMO differed substantially by ECMO modality, ranging from 37.2% among adults receiving venovenous ECMO to 74.4% among adults receiving ECPR. Functional outcomes were inconsistently reported, limiting the understanding of functional recovery among survivors.
Study context
- Population
- Critically ill adults treated with extracorporeal membrane oxygenation (ECMO)
- Participants
- 78,053 adults · 163 studies
- Comparison
- ECMO modality: venovenous ECMO vs venoarterial ECMO vs extracorporeal cardiopulmonary resuscitation (ECPR)
- Outcome
- Long-term all-cause mortality
- Follow-up
- 1 year
Methodological detailsrandom-effects meta-analysis, prespecified subgroup analyses, PRISMA 2020
- Random-effects meta-analysis
- Prespecified subgroup analyses
- PRISMA 2020
Pooled result
As reported in the abstract
Pooled mortality
Further pooled results
Functional outcomes
- Cerebral Performance Category used in 20 of 38 studies
- 52.6%
- WHO Disability Assessment Schedule 2.0 used in 5 of 38 studies
- 13.2%
- Modified Rankin Scale used in 5 of 38 studies
- 13.2%
- Reported in 38 of 163 studies (23.3%) in 7,876 survivors
- Narratively synthesized due to heterogeneity
Original publication
Long-Term Mortality and Functional Outcomes After Extracorporeal Membrane Oxygenation in Critically Ill Adults: A Systematic Review and Meta-Analysis. Crit Care Med. Published 31 August 2026. doi:10.
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