Respiratory failure & ventilation
Association Between Baseline Driving Pressure and Mortality in Very Old Patients with Acute Respiratory Distress Syndrome
Authors' conclusion
Data from randomized controlled trials with strict inclusion criteria suggest that the effect of driving pressure on the mortality of patients with ARDS may depend on age.
Study context
- Population
- Patients with ARDS across the adult lifespan, including very old (⩾80 yr)ARDSNet cohort
- Participants
- 4,567 patients
- Comparison
- Association of baseline driving pressure with 90-day mortality across age (age as continuous variable)
- Primary endpoint
- 90-day mortality (interaction between age and baseline driving pressure)
- Follow-up
- 90 days
Methodological detailsindependent national validation cohort (Hellenic cohort), binary logistic and Cox regression with age × driving pressure interaction
- Independent national validation cohort (Hellenic cohort)
- Binary logistic and Cox regression with age × driving pressure interaction
Primary result
As reported in the abstract
Interaction between age and driving pressure on mortality
- Effect of driving pressure on mortality depended on age (interaction P)
- P = 0.01
- Difference in driving pressure between survivors and nonsurvivors significantly changed across the adult lifespan
- P < 0.01
Further findings
- Driving pressure threshold associated with mortality in very old patients, in both cohorts (cm H2O)
- 11
Original publication
Association Between Baseline Driving Pressure and Mortality in Very Old Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. Published 1 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →