Respiratory failure & ventilation
Association Between Driving Pressure and Subsequent Development of Acute Kidney Injury in Acute Respiratory Distress Syndrome
Primary result · Late AKIResult — go to the resultOdds ratio 1.35 95% CI 1.15–1.58Authors' conclusion
Driving pressure was associated with subsequent development of AKI in patients with ARDS suggesting that injurious mechanical ventilation may lead to AKI.
Study context
- Population
- Adults with ARDS in ICUs of ARDS Network and PETAL Network trials, excluding early acute kidney injury (AKI) (within first 2 d of ARDS onset)5,367 initially enrolled
- Participants
- 2,960 adults
- Comparison
- Baseline driving pressure and late AKI vs no AKI
- Late AKIn = 1,000
Methodological detailsmulticentre
- Multicentre
Primary result
Late AKI
Odds ratio
1.35
95% CI 1.15–1.58
Events by treatment group
Late AKI
33.8%
1000
Each 1 SD increase in driving pressure
OR 1.35 (95% CI 1.15–1.58)
Each 1 SD increase in driving pressure, as printed
As reported in the abstract
Further findings
Sensitivity analyses (not excluding early AKI; including AKI later than 7 days)
- Association persisted
Driving pressure threshold for association with late AKI
- Threshold of driving pressure
- 15 cm H 2 O
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Driving Pressure and Subsequent Development of Acute Kidney Injury in Acute Respiratory Distress Syndrome. Crit Care Med. Published 2 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →