Respiratory failure & ventilation
Congestive heart failure in patients with acute respiratory distress syndrome: A secondary analysis of large randomized controlled trials
Authors' conclusion
Representation of patients with congestive heart failure in ARDS randomized controlled trials increased over time, potentially through the inclusion of frail patients with more advanced disease and due to changing diagnostic criteria of congestive heart failure. Mortality did not change over time, and its association with congestive heart failure did not depend on age.
Study context
- Population
- Patients with ARDS enrolled in ARDS Network and PETAL Network RCTs
- Participants
- 3,800 patients · 6 RCTs
- Comparison
- Patients with vs without comorbid congestive heart failure
- Congestive heart failuren = 240
- Primary endpoint
- Temporal trends of representation and mortality of patients with comorbid congestive heart failure
Methodological detailsindividual patient-level data, exploratory, The two most recent, but not the earliest, trials included patients with New York Heart Association (NYHA) IV cardiac failure
- Individual patient-level data
- Exploratory
- The two most recent, but not the earliest, trials included patients with NYHA IV cardiac failure
Primary result
As reported in the abstract
Congestive heart failure
6.3%
240
- Representation of patients with congestive heart failure increased over time
- P < 0.001
- Difference in mortality between patients with and without congestive heart failure unchanged over time
- P = 0.317
Further findings
90-day all-cause mortality: association with congestive heart failure by age
- Association did not depend on age
- P = 0.669
Original publication
Congestive heart failure in patients with acute respiratory distress syndrome: A secondary analysis of large randomized controlled trials. Anaesth Crit Care Pain Med. Published 20 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →