Respiratory failure & ventilation
The Relationship Between Metabolic Syndrome and Mortality Among Patients With Acute Respiratory Distress Syndrome in Acute Respiratory Distress Syndrome Network and Prevention and Early Treatment of Acute Lung Injury Network Trials*
Main finding · 28-day mortalityResult — go to the resultAdjusted odds ratio 0.70 95% CI 0.55–0.89Authors' conclusion
Metabolic syndrome in ARDS was associated with a lower risk of mortality in non-COVID-19 ARDS.
Study context
- Population
- Hospitalised patients with non-COVID-19 acute respiratory distress syndrome (ARDS) in ARDS Network and PETAL Network trials
- Participants
- 4,288 patients · 7 RCTs
- Exposure
- Metabolic syndrome vs control
- Metabolic syndromen = 454
- Controln = 3,834reference
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsancillary analysis of seven randomised trials
- Ancillary analysis of seven randomised trials
Main finding
As reported in the abstract
Adjusted odds ratio
0.70
95% CI 0.55–0.89
Metabolic syndrome vs Control
aOR 0.70 (95% CI 0.55–0.89)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| 90-day mortality · adjusted analyses | 0.75 (0.60–0.95) | |
| Mortality, ARDS from sepsis or pneumonia (subgroup)Metabolic syndrome vs Control · 28 d | 0.64 (0.48–0.84) | |
| Mortality, ARDS from sepsis or pneumonia (subgroup)Metabolic syndrome vs Control · 90 d | 0.69 (0.53–0.89) | |
| Mortality, ARDS from noninfectious causes (subgroup)Metabolic syndrome vs Control · 28 d | 1.18 (0.70–1.99) | |
| Mortality, ARDS from noninfectious causes (subgroup)Metabolic syndrome vs Control · 90 d | 1.26 (0.77–2.06) | |
| 0.512Adjusted odds ratio (log scale) |
- Mortality, ARDS from sepsis or pneumonia (subgroup): interaction p = 0.04 (28 d) and p = 0.02 (90 d)
- Mortality, ARDS from noninfectious causes (subgroup): interaction p = 0.04 (28 d) and p = 0.02 (90 d)
Adjusted 28-day mortality by number of metabolic criteria
- Reduction with each additional metabolic criterion from 0 to 3
- 18%, 22%, and 40%
Original publication
The Relationship Between Metabolic Syndrome and Mortality Among Patients With Acute Respiratory Distress Syndrome in Acute Respiratory Distress Syndrome Network and Prevention and Early Treatment of Acute Lung Injury Network Trials*. Crit Care Med. Published 1 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →