Respiratory failure & ventilation
Intubation Decision Based on Illness Severity and Mortality in COVID-19: An International Study*
Main findingResult — go to the resultAdjusted hazard ratio 0.68 95% CI 0.52–0.90Authors' conclusion
In severe COVID-19 cases, an early intubation strategy, guided by specific severity criteria, is associated with a reduced risk of death.
Study context
- Population
- Adults hospitalised for COVID-19 requiring intubation after admission, 10 academic institutions in the US and Europe, 2020–2022of 4464 patients
- Participants
- 854 adults
- Exposure
- Early invasive mechanical ventilation (EIMV) vs late invasive mechanical ventilation (LIMV)
- EIMVn = 621
- LIMVn = 233reference
- Outcome
- Mortality
- Follow-up
- 30 days of hospital admission
Methodological detailsmulticentre, international, inverse probability-of-treatment weighting
- Multicentre
- International
- Inverse probability-of-treatment weighting
Main finding
As reported in the abstract
Adjusted hazard ratio
0.68
95% CI 0.52–0.90
P = 0.008
Events by group
EIMV vs LIMV
aHR 0.68 (95% CI 0.52–0.90); P = 0.008
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| Mortality within 30 days after intubationInverse probability-of-treatment weighting | 0.70 (0.51–0.90) | P = 0.006 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Intubation Decision Based on Illness Severity and Mortality in COVID-19: An International Study*. Crit Care Med. Published 23 February 2024. doi:10.
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