Cardiothoracic & vascular anaesthesia
Continuous positive airway pressure to prevent reintubation in patients recovering from cardiac surgery: A multicentre randomised clinical trial
- prematurely terminated (underpowered)
Authors' conclusion
CPAP did not significantly reduce 28-day reintubation rates compared with oxygen therapy via Venturi mask. However, CPAP was associated with a significant reduction in atelectasis and early reintubation at 48 h.
Study context
- Population
- Adults after cardiac surgery with CPB with PaO2/FiO2 ratio 200 or less within 1 h of extubation; 10 university-affiliated hospitals, Italy
- Comparison
- Continuous positive airway pressure (CPAP) vs oxygen therapy via Venturi mask
- Primary endpoint
- Reintubation
- Follow-up
- Within 28 days of surgery
Methodological detailsmulticentre, open-label
- Multicentre
- Open-label
Primary result
As reported in the abstract
28 days
P = 0.3908
Secondary outcomes
| Outcome | CPAP | Control | P value |
|---|---|---|---|
| Atelectasis | 14.2% (95% CI 9.38–19.05) | 24.1% (95% CI 18.20–30.07) | P = 0.0110 |
| Reintubation at 48 h | 2.94% (95% CI 0.60–5.28) | 7.39% (95% CI 3.76–11.02) | P = 0.0425 |
| OxygenationCPAP significantly improved oxygenation | P < 0.0001 |
Pneumonia, sepsis, mortality
- No significant differences
Original publication
Continuous positive airway pressure to prevent reintubation in patients recovering from cardiac surgery: A multicentre randomised clinical trial. Eur J Anaesthesiol. Published 27 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →