Cardiothoracic & vascular anesthesia

Association between postoperative acute hypoxaemic respiratory failure and hospital mortality in patients undergoing cardiac surgery: A multicenter registry-based retrospective study

Anaesth Crit Care Pain MedPublished Retrospective cohort study

Main findingResult — go to the resultAdjusted odds ratio 1.56 95% CI 1.33–1.82

Authors' conclusion

In this large cohort of cardiac surgery patients, AHRF was common and significantly associated with increased hospital mortality.

Study context

Population
Adults (≥ 16 years) admitted to ICU after coronary artery bypass grafting (CABG), valvular surgery or combined procedures, ANZICS Adult Patient Database, January 2018–December 2022
Participants
86,214 adults
Exposure
Acute hypoxemic respiratory failure (AHRF) vs no AHRF
  • AHRFn = 54,044
Outcome
Hospital mortality
Methodological detailsmulticentre, registry-based
  • Multicentre
  • Registry-based

Main finding

As reported in the abstract

Adjusted odds ratio

1.56

95% CI 1.33–1.82

By group

AHRF vs No AHRF
aOR 1.56 (95% CI 1.33–1.82)
Overall hospital mortality
1.1%

Observational data: associations, not effects.

Secondary outcomes

AHRF incidence

Patients with AHRF
62.7%

Original publication

Association between postoperative acute hypoxaemic respiratory failure and hospital mortality in patients undergoing cardiac surgery: A multicenter registry-based retrospective study. Anaesth Crit Care Pain Med. Published 30 October 2025. doi:10.1016/j.accpm.2025.101659

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