Cardiothoracic & vascular anesthesia
Prospective Randomized Pilot Trial on the Effects of Mild Hypercapnia on Cerebral Oxygen Saturation in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting
Authors' conclusion
TMH during grafting increased the cerebral blood flow and rSO2 when hemodynamic instability was very common.
Study context
- Population
- Patients undergoing off-pump Coronary Artery Bypass Grafting (CABG), U. N. Mehta Hospital, Ahmedabad, India
- Participants
- 100 patients
- Comparison
- Targeted mild hypercapnia vs targeted normocapnia
- Targeted mild hypercapnia (TMH)n = 50
- Targeted normocapnia (TN)n = 50reference
- Primary endpoint
- Cerebral oxygen saturation (rSO2)
Methodological detailssingle-centre, pilot, prospective
- Single-centre
- Pilot
- Prospective
Primary result
As reported in the abstract
rSO2
- Higher rSO2 on both sides during distal and proximal grafting in TMH vs TN
- p < 0.001
- Higher rSO2 after protamine in TMH vs TN
- p < 0.05
Further findings
Mean arterial pressure (MAP) during grafting
- Higher MAP during grafting in TMH vs TN
- P < 0.001
SMMSE scores vs preoperative values · 12 and 24 hours postextubation
- SMMSE scores significantly lower than preoperative in TN
- P < 0.001
Original publication
Prospective Randomized Pilot Trial on the Effects of Mild Hypercapnia on Cerebral Oxygen Saturation in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting. J Cardiothorac Vasc Anesth. Published 6 March 2024. doi:10.
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