Neuroanaesthesia & neurocritical care
Association between cerebral autoregulation and optimal cerebral perfusion pressure after hypertensive intracerebral hemorrhage under neuromultimodal monitoring
Authors' conclusion
Both cerebral autoregulatory function and intracranial compensatory reserve are closely associated with CPPopt in HICH. Maintaining CPP near CPPopt simultaneously optimizes cerebral physiological status; hypoperfusion and elevated ICP cause more severe impairment than hyperperfusion.
Study context
- Population
- Patients with hypertensive intracerebral hemorrhage (HICH) undergoing multimodal neuromonitoring (PRx, RAP, Mx, COx)
- Participants
- 97 patients
- Exposure
- ΔCPPopt categories
- Outcome
- Cerebral autoregulation and compensatory reserve indices by ΔCPPopt
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
| Group | Value | PRx | Mx | COx | RAP |
|---|---|---|---|---|---|
| ΔCPPopt −5 to 5 mmHg | 0.03 ± 0.06 | 0.03 ± 0.06 | 0.07 ± 0.07 | 0.02 ± 0.05 | 0.17 ± 0.05 |
ΔCPPopt −5 to 5 mmHg
Value0.03 ± 0.06
PRx0.03 ± 0.06
Mx0.07 ± 0.07
COx0.02 ± 0.05
RAP0.17 ± 0.05
- ΔCPPopt −5 to 5 mmHg vs other groups: P < 0.001 — RAP significantly lower than other groups
Observational data: associations, not effects.
Original publication
Association between cerebral autoregulation and optimal cerebral perfusion pressure after hypertensive intracerebral hemorrhage under neuromultimodal monitoring. J Crit Care. Published 24 September 2026. doi:10.
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