Respiratory failure & ventilation
Association between controlled mechanical ventilation and systemic inflammation in acute hypoxemic respiratory failure: an observational cohort study
Authors' conclusion
In patients with acute hypoxemic respiratory failure initially breathing spontaneously, transition to CMV was associated with reduced IL-6 levels and improved ventilatory homogeneity over 24 h.
Study context
- Population
- ICU patients with acute hypoxemic respiratory failure initially breathing spontaneously
- Participants
- 40 patients
- Exposure
- Transition to controlled mechanical ventilation (CMV) vs continued spontaneous breathing
- CMVn = 28
- SBn = 12reference
- Outcome
- IL-6 levels, CMV group, baseline vs 24 h
- Follow-up
- 24 h
Methodological detailsGroup allocation based on clinical decisions
- Group allocation based on clinical decisions
Main finding
As reported in the abstract
- IL-6 baseline (CMV), mean ± SD, pg/mL
- 305 ± 938
- IL-6 at 24 h (CMV), mean ± SD, pg/mL
- 27 ± 58
- Change over time, P
- p = 0.0195
Observational data: associations, not effects.
Further findings
Oxygenation (PaO2/FiO2), CMV group · 24 h
- PaO2/FiO2 baseline to 24 h (CMV)
- 140 ± 51 to 199 ± 67
- P
- P = 0.0004
- SB: no significant changes in gas exchange
Electrical impedance tomography (EIT) ventilation distribution · 24 h
- CMV: increased end-expiratory lung impedance, decreased global inhomogeneity, dorsal shift of center of ventilation
- SB: no significant changes in EIT-derived parameters
Respiratory rate and heart rate, CMV group
- Decreased significantly over time
Original publication
Association between controlled mechanical ventilation and systemic inflammation in acute hypoxemic respiratory failure: an observational cohort study. Crit Care. Published 11 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →