Neuroanesthesia & neurocritical care
Association Between Coronavirus Disease 2019 Vaccination and Mortality After Major Operations
Main findingResult — go to the resultAdjusted odds ratio 1.38 95% CI 0.70–2.72Authors' conclusion
Contrary to risks observed among unvaccinated patients, postoperative mortality does not differ between patients with and without COVID-19 when vaccinated against the severe acute respiratory syndrome coronavirus 2 virus and receiving a high-risk operation within 8 weeks of the diagnosis, regardless of operation timing relative to diagnosis.
Study context
- Population
- Fully vaccinated patients undergoing high-risk general, vascular, orthopedic, neurosurgery or genitourinary surgery, US, July 2021 to October 2022fully vaccinated
- Participants
- 3,401 participants
- Exposure
- COVID-19-positive vs COVID-19-negative
- COVID-19-positiven = 437
- Outcome
- All-cause mortality
- Follow-up
- 90 days
Methodological detailsmatched cohort, multicentre, national US, inverse probability treatment weighted propensity scores
- Matched cohort
- Multicentre
- National US
- Inverse probability treatment weighted propensity scores
Main finding
As reported in the abstract
Adjusted odds ratio
1.38
95% CI 0.70–2.72
Events by group
COVID-19-positive vs COVID-19-negative
aOR 1.38 (95% CI 0.70–2.72)
Observational data: associations, not effects.
Further findings
Proximity of COVID-19 diagnosis to operation
- Did not confer added mortality risk in either comparison cohort
Original publication
Association Between Coronavirus Disease 2019 Vaccination and Mortality After Major Operations. Ann Surg. Published 27 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →