Neuroanaesthesia & neurocritical care
Clinical effectiveness of intravenous hypertonic sodium lactate infusion for intra-operative brain relaxation in supratentorial brain tumour surgery: A double-blind randomised phase II pilot study
Authors' conclusion
Pilot data suggests that HSL could provide efficient brain relaxation in patients undergoing supratentorial brain tumour resection via craniotomy
Study context
- Population
- Adults undergoing planned supratentorial brain tumour surgery, tertiary neurosurgery centregroups' n as analysed
- Participants
- 24 vs 22
- Comparison
- Interventional vs Conventional
- Interventionaln = 24
- Conventionaln = 22reference
- Primary endpoint
- Proportion of patients with satisfactory brain relaxation, assessed by the surgeon after opening the dura on a validated 4-point scale
- Follow-up
- After opening the dura
Methodological detailsdouble-blind, phase II, pilot, single-centre
- Double-blind
- Phase II
- Pilot
- Single-centre
Primary result
As reported in the abstract
Satisfactory brain relaxation
P = 0.60
Secondary outcomes
| Outcome | Interventional |
|---|---|
| Blood lactate level · peak at T 0 +30 min | median 8.20 (IQR 6.98–8.73) mmol l −1 |
Blood lactate level · peak at T 0 +30 min
- Lactate higher in the interventional than the conventional group at each time point (T 0 +30, +60, +180 min)
Safety
| Outcome | HSL | Mannitol |
|---|---|---|
| Hypokalaemia | Six events | one events |
Adverse events related to hypertonic sodium lactate (HSL) infusion
- No adverse events related to HSL infusion observed
Original publication
Clinical effectiveness of intravenous hypertonic sodium lactate infusion for intra-operative brain relaxation in supratentorial brain tumour surgery: A double-blind randomised phase II pilot study. Eur J Anaesthesiol. Published 8 May 2026. doi:10.
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