ICU sedation, delirium & recovery
Association between days alive without life support/out of hospital and health‐related quality of life
Authors' conclusion
DAWOLS and DAOOH were poorly associated with HRQoL in adult survivors of severe or critical illness included in the COVID STEROID 2 and HOT-ICU trials.
Study context
- Population
- Adults with COVID-19 and severe hypoxaemia (COVID STEROID 2) and adult ICU patients with acute hypoxaemic respiratory failure (HOT-ICU)
- Primary endpoint
- Associations between DAWOLS and DAOOH and long-term HRQoL (EQ VAS and EQ-5D-5L index values)
- Follow-up
- DAWOLS/DAOOH at day 28 and 90; HRQoL after 6 or 12 months
Methodological detailsinternal performance and external validation
- Internal performance and external validation
Primary result
As reported in the abstract
Association of DAWOLS/DAOOH with HRQoL in survivors
- No strong associations between days alive without life support (DAWOLS) or days alive out of hospital (DAOOH) and health-related quality of life (HRQoL) in survivors at HRQoL follow-up (615 and 1476 patients, respectively)
- Predictions from best fitted models poor internally and externally, with inadequate calibration
Further findings
Association including non-survivors
- Moderate associations; predictions uncertain and calibration inadequate
Original publication
Association between days alive without life support/out of hospital and health‐related quality of life. Acta Anaesthesiol Scand. Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →