Association between Ehlers-Danlos syndrome and complex regional pain syndrome: a large nationwide claims database study
Authors' conclusion
Patients with EDS had a substantially higher proportion of recorded CRPS diagnoses than patients without EDS in this national claims dataset.
Study context
- Population
- Commercially insured US patients, Merative MarketScan 2017–2022
- Participants
- 54,235,476 participants
- Exposure
- Ehlers-Danlos syndrome (EDS) vs no EDS
- EDSn = 26,053
- Without EDSn = 54,158,272reference
- Outcome
- Recorded CRPS diagnoses (ICD-10-CM: G90.5x, G56.4x, G57.7x)
Methodological detailsnationwide claims database
- Nationwide claims database
Main finding
As reported in the abstract
CRPS diagnosis after EDS diagnosis
95% CI 9.89–12.51
Observational data: associations, not effects.
Further findings
Co-occurrence of EDS and complex regional pain syndrome (CRPS)
- CRPS diagnosis before EDS diagnosis
- 217
- Co-occurrence regardless of order
- 490
Female sex among EDS patients, with vs without CRPS
- With CRPS
- 96.7%
- Without CRPS
- 81.3%
- Median age, years
- 27
CRPS characteristics among CRPS cases
- Type 1 disease
- 76.8%
- Lower-limb involvement
- 49.0%
Original publication
Association between Ehlers-Danlos syndrome and complex regional pain syndrome: a large nationwide claims database study. Reg Anesth Pain Med. Published 3 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →