Association between elevated lactate and clinical outcomes in adults with diabetic ketoacidosis
Main finding · In-hospital mortalityResult — go to the resultOdds ratio 1.785 95% CI 1.122–2.841Authors' conclusion
Hyperlactatemia in patients admitted to ICU with DKA is associated with higher mortality, longer hospital and ICU LOS, and higher rates of mechanical ventilation, RRT and inotropes.
Study context
- Population
- Adults admitted to intensive care unit (ICU) with a primary diagnosis of diabetic ketoacidosis (DKA) in Australia and New Zealand
- Participants
- 9,061 adults
- Exposure
- Hyperlactatemia vs normolactatemia
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, pre-existing dataset
- Multicentre
- Pre-existing dataset
Main finding
As reported in the abstract
Odds ratio
1.785
95% CI 1.122–2.841
P = 0.014
Hyperlactatemia vs Normolactatemia
OR 1.785 (95% CI 1.122–2.841); P = 0.014
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimate | P value | |
|---|---|---|---|
| Hospital LOS | Geometric mean ratio 1.063 (95% CI 1.025–1.103) | P = 0.001 | |
| ICU LOS | Geometric mean ratio 1.057 (95% CI 1.026–1.09) | P < 0.001 | |
| RRT | OR 2.198 (95% CI 1.449–3.334) | P < 0.001 | |
| Inotropes | OR 1.578 (95% CI 1.311–1.899) | P < 0.001 | |
| 0.20.5125Ratio (log scale) |
Associations by diabetes type (subgroup)
- Associations persisted in Type 2 but not Type 1 diabetics
Original publication
Association between elevated lactate and clinical outcomes in adults with diabetic ketoacidosis. J Crit Care. Published 19 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →