Paediatric anaesthesia & critical care
Association Between Extreme Weight-for-Age and Airway-Related Adverse Events During Anesthesia Induction: An Analysis Using the J-PEDIA Registry Data
Authors' conclusion
Obese and underweight status were associated with desaturation, whereas underweight status was additionally associated with lower odds of successful first-attempt tracheal intubation during the induction of general anesthesia.
Study context
- Population
- Children aged <18 years undergoing tracheal intubation at initial GA induction, Japanese Pediatric Difficult Airway Registry, 12 tertiary care hospitals, June 2022 to February 2025encounters analysed
- Participants
- 18,835 children
- Exposure
- Obese, overweight or underweight vs normal weight-for-age
- Normaln = 14,546reference
- Obesen = 667
- Overweightn = 1,403
- Underweightn = 2,219
- Outcome
- ARAEs
Methodological detailsmulticentre, registry-based, multilevel mixed-effects logistic regression
- Multicentre
- Registry-based
- Multilevel mixed-effects logistic regression
Main finding
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Normal | Obese | Overweight | Underweight | aOR (95% CI) | P value | |
|---|---|---|---|---|---|---|---|
| First-attempt tracheal intubation successUnderweight vs Normal | 89.2% | 91.6% | 91.4% | 80.5% | 0.69 (0.60–0.79) | P < 0.001 | |
| Desaturation ≥10% (SpO2 drop ≥10% during the encounter)Obese vs Normal | 2.12 (1.17–3.84) | P = 0.013 | |||||
| Desaturation ≥10% (SpO2 drop ≥10% during the encounter)Underweight vs Normal | 1.31 (1.05–1.64) | P = 0.017 | |||||
| 0.20.5125Adjusted odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Extreme Weight-for-Age and Airway-Related Adverse Events During Anesthesia Induction: An Analysis Using the J-PEDIA Registry Data. Anesth Analg. Published 9 September 2026. doi:10.
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