Association between hyperoxia and mortality in patients undergoing extracorporeal membrane oxygenation: A systematic review and meta-analysis
Pooled result · MortalityResult — go to the resultOdds ratio 1.41 95 % CI 1.22–1.64Authors' conclusion
In this systematic review and meta-analysis of twelve studies investigating arterial oxygenation and mortality in adult ECMO patients, early hyperoxia-particularly at very high PaO₂ levels-was associated with increased mortality in several observational cohorts, most notably among VA-ECMO and ECPR populations.
Study context
- Population
- Adult extracorporeal membrane oxygenation (ECMO) patients
- Participants
- 17,529 patients · 12 studies
- Comparison
- Arterial hyperoxia vs no hyperoxia
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsPRISMA guidelines
- PRISMA guidelines
Pooled result
Mortality
Odds ratio
1.41
95 % CI 1.22–1.64
P < 0.01
Hyperoxia vs No hyperoxia
OR 1.41 (95 % CI 1.22–1.64); P < 0.01
As reported in the abstract
Further pooled results
Mortality by PaO₂ threshold and ECMO type (subgroup)
- Higher mortality with PaO₂ ≥200 mmHg and ≥ 300 mmHg, particularly in VA-ECMO and ECPR
- No significant association in VV-ECMO
Sensitivity analyses
- Supported stability of most results; potential publication bias could not be ruled out
Original publication
Association between hyperoxia and mortality in patients undergoing extracorporeal membrane oxygenation: A systematic review and meta-analysis. J Crit Care. Published 14 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →