The association between introduction of the micro-axial flow pump Impella in hospitals and in-hospital mortality in patients treated with extracorporeal membrane oxygenation: interrupted time-series analyses
Authors' conclusion
This nationwide inpatient database study showed no association between Impella introduction in hospitals and in-hospital mortality of patients who underwent ECMO.
Study context
- Population
- Patients who received extracorporeal membrane oxygenation (ECMO) during hospitalization, nationwide Japanese inpatient database, 1 April 2014 to 31 March 202134,379 eligible
- Participants
- 8,351 vs 7,230
- Exposure
- Hospitals that introduced Impella vs hospitals that did not, before vs after exposure
- Exposuren = 8,351
- Controln = 7,230reference
- Outcome
- In-hospital mortality
Methodological detailsnationwide inpatient database, hospital-level propensity score-matched, uncontrolled and controlled interrupted time-series
- Nationwide inpatient database
- Hospital-level propensity score-matched
- Uncontrolled and controlled interrupted time-series
Main finding
As reported in the abstract
Each group vs controlLevel change (95% CI)
Exposure
−0.01%(−5.36% to + 5.33%)
- Exposure
- trend change + 0.10% (95% CI −0.30% to + 0.40%)
Observational data: associations, not effects.
Original publication
The association between introduction of the micro-axial flow pump Impella in hospitals and in-hospital mortality in patients treated with extracorporeal membrane oxygenation: interrupted time-series analyses. Ann Intensive Care. Published 28 September 2024. doi:10.
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