Age-associated outcomes in cardiogenic shock supported with microaxial flow pumps
Authors' conclusion
In this European registry, increasing age was associated with higher mortality and lower observed myocardial recovery among patients with cardiogenic shock supported with mAFP.
Study context
- Population
- Patients with cardiogenic shock (CS) treated with micro-Axial Flow Pump (mAFP) (Impella CP, 5.0 and 5.5), 11 European centers, 2010–2023
- Participants
- 1,043 patients
- Exposure
- Age quartiles Q2, Q3, Q4 vs Q1
- Outcome
- All-cause mortality
- Follow-up
- 30 days
Methodological details11 European centers, Fine-Gray competing risks model, restricted cubic spline analysis
- 11 European centers
- Fine-Gray competing risks model
- Restricted cubic spline analysis
Main finding
As reported in the abstract
30-day all-cause mortality
Adjusted subdistribution hazard ratio (95% CI)P value
Q3 vs Q1
1.66(1.19–2.34)
P < 0.01for trendQ4 vs Q1
1.87(1.34–2.62)
P < 0.01for trendEach additional year of age3.2% increase in 30-day mortality risk per year
1.032(1.017–1.047)
Observational data: associations, not effects.
Further findings
| Outcome | sHR (CI) | P value | |
|---|---|---|---|
| 1-year mortalityQ3 vs Q1 · Fine-Gray competing risks model | 1.78 (1.31–2.41) | P for trend < 0.01 | |
| 1-year mortalityQ4 vs Q1 · Fine-Gray competing risks model | 2.08 (1.54–2.80) | P for trend < 0.01 | |
| 0.20.5125Subdistribution hazard ratio (log scale) |
| Outcome | Q1 | Q4 | P value |
|---|---|---|---|
| Major LVEF recovery (≥10 percentage points)Q4 vs Q1 | 74.5% | 41.9% | P < 0.01 |
- Major left ventricular ejection fraction (LVEF) recovery (≥10 percentage points) — Reduction in LVEF improvement per year of age
- 0.40 percentage-point
Major LVEF recovery (≥10 percentage points)
- Major LVEF recovery declined progressively with age
Baseline characteristics, Q4 vs Q1
- Q4 more frequently female, higher comorbidity burden, less intensive support than Q1
Original publication
Age-associated outcomes in cardiogenic shock supported with microaxial flow pumps. Ann Intensive Care. Published 24 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →