UNLOADERS-PVAD Weaning Score: predicting post-weaning adverse events in cardiogenic shock patients supported by microaxial flow pump
Authors' conclusion
Four clinical and three hemodynamic factors were significantly associated with 30-day events following PVAD weaning, leading to the development of the UNLOADERS-PVAD Weaning Score.
Study context
- Population
- Patients with cardiogenic shock supported by PVAD (microaxial flow pump) undergoing weaning, three institutions in Japan
- Participants
- 304 patients
- Primary endpoint
- 30-day events: all-cause mortality or reintroduction of mechanical circulatory support after PVAD weaning
- Follow-up
- 30 days
Methodological detailsprognostic model development, multicentre, consecutive patients, least absolute shrinkage and selection operator (LASSO) variable selection
- Prognostic model development
- Multicentre
- Consecutive patients
- LASSO variable selection
Primary result
As reported in the abstract
UNLOADERS-PVAD Weaning Score predicting 30-day events
Score stratified 30-day event risk linearly; AUC
0.786
95% CI 0.712–0.860
Original publication
UNLOADERS-PVAD Weaning Score: predicting post-weaning adverse events in cardiogenic shock patients supported by microaxial flow pump. J Intensive Care. Published 4 November 2025. doi:10.
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