Neuroanesthesia & neurocritical care
Association between invasive intracranial pressure monitoring and 1-year functional outcome in ICU patients with severe stroke: a pre-planned ancillary study of the SPICE prospective cohort (SPICE-ICP)
Authors' conclusion
ICP monitoring in severe stroke is more commonly employed in younger patients with fewer comorbidities. This monitoring does not appear to be an independent protective factor for a favourable one-year functional outcome when adjusted for confounders.
Study context
- Population
- ICU patients with severe stroke requiring mechanical ventilationSPICE cohort
- Participants
- 356 patients
- Exposure
- Intracranial pressure (ICP) monitoring vs standard monitoring
- ICPn = 129
- Outcome
- Unfavourable functional outcome (modified Rankin Scale score 4–6)
- Follow-up
- 1 year
Methodological detailsmultivariate logistic regression, propensity score weighting
- Multivariate logistic regression
- Propensity score weighting
Main finding
As reported in the abstract
ICP vs Standard monitoringOdds ratio (95% CI)
Unadjusted
0.43(0.27–0.68)
Adjusted for age, GCS, Charlson index, septic shock, cerebral oedema, anisocoria
0.38(0.22–0.67)
Propensity score-weighted; not statistically significant
0.90(0.80–1.01)
Observational data: associations, not effects.
Further findings
Baseline characteristics
- ICP patients younger, fewer comorbidities, less severe clinical presentation
Original publication
Association between invasive intracranial pressure monitoring and 1-year functional outcome in ICU patients with severe stroke: a pre-planned ancillary study of the SPICE prospective cohort (SPICE-ICP). Anaesth Crit Care Pain Med. Published 23 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →