Association between lactate clearance rate and 28-day mortality in patients with sepsis: a retrospective cohort study and exploration of an optimal lactate clearance as an endpoint of resuscitation
Main finding · 28-day mortality by LCRperhourResult — go to the resultOdds ratio 0.03 95% CI 0.01–0.09Authors' conclusion
In patients with sepsis, the relationship between lactate clearance during resuscitation and 28-day mortality was nonlinear. The mortality rate declined steeply with increasing lactate clearance until a point was reached, after which the survival benefit plateaued.
Study context
- Population
- Patients with sepsis with peak lactate ≥ 2 mmol·L-1 within 24 hr of intensive care unit (ICU) admission (Medical Information Mart for Intensive Care IV (MIMIC-IV) and eICU databases)met inclusion criteria
- Participants
- 13,586 patients
- Exposure
- Lactate clearance rate per hour ≥ 0.11 vs < 0.11
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsmultivariable logistic regression, adjusted restricted cubic spline model, MIMIC-IV and eICU databases
- Multivariable logistic regression
- Adjusted restricted cubic spline model
- MIMIC-IV and eICU databases
Main finding
28-day mortality by LCRperhour
Odds ratio
0.03
95% CI 0.01–0.09
P < 0.001
Lactate clearance rate per hour (LCRperhour) ≥ 0.11 vs < 0.11
OR 0.03 (95% CI 0.01–0.09); P < 0.001
As reported in the abstract
- Overall 28-day deaths
- 3,313 (24.4%)
- Inflection point on the OR curve at lactate clearance rate per hour (LCRperhour)
- 0.11
Observational data: associations, not effects.
Further findings
28-day mortality, Lacpeak > 4 mmol·L-1 and 2-4 mmol·L-1 (subgroups)
- Mortality significantly lower with LCRperhour ≥ 0.11 than < 0.11 in both subgroups (both P < 0.05)
Original publication
Association between lactate clearance rate and 28-day mortality in patients with sepsis: a retrospective cohort study and exploration of an optimal lactate clearance as an endpoint of resuscitation. Can J Anaesth. Published 22 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →