Association Between Levels of Intensive Care and In-Hospital Mortality in Patients Hospitalized for Sepsis Stratified by Sequential Organ Failure Assessment Scores*
Authors' conclusion
Patients hospitalized for sepsis with SOFA scores greater than or equal to 6 in the ICU or HDU had lower in-hospital mortality than those in the general ward, as did those with SOFA scores greater than or equal to 12 in the ICU versus HDU.
Study context
- Population
- Adults hospitalized for sepsis with Sequential Organ Failure Assessment (SOFA) ≥2 on admission day, Japanese national inpatient database, April 2018–March 2021
- Participants
- 97,070 adults
- Exposure
- ICU + HDU vs general ward; ICU vs HDU
- ICUn = 19,770
- HDUn = 23,066
- General wardn = 54,234reference
- Outcome
- In-hospital mortality by SOFA stratum (subgroup)
Methodological detailsnationwide, propensity score-matched
- Nationwide
- Propensity score-matched
Main finding
As reported in the abstract
- ICU + HDU vs general ward, SOFA ≥6: significantly lower mortality with ICU + HDU
- ICU + HDU vs general ward, SOFA 3-5: no significant difference
- ICU + HDU vs general ward, SOFA 2: significantly higher mortality with ICU + HDU
- ICU vs HDU, SOFA ≥12: lower mortality with ICU
- ICU vs HDU, SOFA 5-11: no significant difference
- ICU vs general ward, SOFA ≤4: significantly higher mortality with ICU
- Propensity score-matched
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Levels of Intensive Care and In-Hospital Mortality in Patients Hospitalized for Sepsis Stratified by Sequential Organ Failure Assessment Scores*. Crit Care Med. Published 28 April 2023. doi:10.
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