Association between obesity and kidney outcomes in critically ill patients with acute kidney injury receiving continuous renal replacement therapy: a secondary analysis of the multicenter CRRTnet study
Authors' conclusion
Among critically ill adults with AKI receiving CRRT, obesity appears to confer greater risk of in-hospital mortality, and greater prescribed CRRT dose-intensity was consistently associated with greater mortality risk across all weight-based indices.
Study context
- Population
- Critically ill adults with AKI receiving continuous renal replacement therapy (CRRT) (≥ 24 h of CRRT)
- Participants
- 890 adults
- Comparison
- Obese vs Non-obese
- Obesen = 478
- Non-obesen = 412reference
- Primary endpoint
- In-hospital mortality, by obesity and by prescribed CRRT dose-intensity (ABW, IBW, Adj-BW)
Methodological detailsmulticentre, multivariable analysis
- Multicentre
- Multivariable analysis
Primary result
As reported in the abstract
In-hospital mortality
Adjusted odds ratio (95% CI)P value
CRRT dose-intensity per 5 mL/kg/h increase, indexed to ABW
1.17(1.10–1.25)
P < 0.001CRRT dose-intensity per 5 mL/kg/h increase, indexed to IBW
1.13(1.09–1.18)
P < 0.001CRRT dose-intensity per 5 mL/kg/h increase, indexed to Adj-BW
1.19(1.13–1.27)
P < 0.001Per 5 mL/kg/h increase, as printed
Further findings
BMI
P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between obesity and kidney outcomes in critically ill patients with acute kidney injury receiving continuous renal replacement therapy: a secondary analysis of the multicenter CRRTnet study. Crit Care. Published 28 March 2026. doi:10.
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