Perioperative medicine & outcomes
Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial
Primary result · Postoperative AKIResult — go to the resultAdjusted odds ratio 1.32 95% CI 1.00–1.74Authors' conclusion
Larger areas and longer cumulative times under thresholds of perfusion index and lower time-weighted average perfusion index were associated with postoperative acute kidney injury in patients undergoing major noncardiac surgery and receiving continuous vasopressor infusions.
Study context
- Population
- Patients undergoing major noncardiac surgery and receiving continuous vasopressor infusions
- Participants
- 2,534 patients
- Comparison
- Intraoperative perfusion index and postoperative AKI
- Primary endpoint
- Postoperative AKI
Methodological detailsexploratory post hoc analysis, pragmatic, cluster-randomised, multicentre
- Exploratory post hoc analysis
- Pragmatic
- Cluster-randomised
- Multicentre
Primary result
As reported in the abstract
Adjusted odds ratio
1.32
95% CI 1.00–1.74
P = 0.050
Area under perfusion index of 1% (per 100%∗min increase)
aOR 1.32 (95% CI 1.00–1.74); P = 0.050
Per 100%∗min increase, as printed
- Incidence of postoperative AKI
- 8.9%
Secondary outcomes
Postoperative AKI, time-weighted average perfusion index
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Time-weighted average perfusion index | 0.82 (0.74–0.91) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
30-day mortality, time-weighted average perfusion index
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Time-weighted average perfusion index | 0.68 (0.49–0.95) | P = 0.024 | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial. Br J Anaesth. Published 19 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →