Perioperative medicine & outcomes
Association between plasma growth differentiation factor-15 and postoperative nausea and vomiting incidence and severity: a secondary analysis of a randomised trial
Authors' conclusion
Lower preoperative plasma GDF-15 concentrations or low-maintaining trajectory were associated with higher odds of PONV in laparoscopic gastrointestinal surgery patients.
Study context
- Population
- At-risk adults undergoing laparoscopic gastrointestinal surgery860 (96.0%) female
- Participants
- 896 adults
- Comparison
- Preoperative GDF-15 tertiles; GDF-15 trajectories
- Primary endpoint
- PONV (nausea, retching, or vomiting)
- Follow-up
- Within 120 h after surgery
Primary result
As reported in the abstract
PONV within 120 h after surgery · 0-120 h after surgery
Adjusted odds ratio (95% CI)P value
Second tertile vs First tertilepreoperative GDF-15
0.63(0.44–0.91)
P = 0.013Third tertile vs First tertilepreoperative GDF-15
0.44(0.30–0.64)
P < 0.001High-increasing vs Low-maintainingGDF-15 trajectory
0.64(0.46–0.89)
P = 0.008- Postoperative nausea and vomiting (PONV) overall
- 531 (59.3%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between plasma growth differentiation factor-15 and postoperative nausea and vomiting incidence and severity: a secondary analysis of a randomised trial. Br J Anaesth. Published 29 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →