Perioperative medicine & outcomes
Association of Preoperative Growth Differentiation Factor-15 Concentrations and Postoperative Cardiovascular Events after Major Noncardiac Surgery
Authors' conclusion
Growth differentiation factor-15 is strongly associated with 30-day risk of major cardiovascular events and significantly improved cardiac risk prediction in patients undergoing noncardiac surgery.
Study context
- Population
- Patients 45 yr or older having major noncardiac surgery
- Participants
- 5,238 patients
- Exposure
- Preoperative GDF-15 categories vs <1,000 pg/ml
- <1,000 pg/mln = 1,705reference
- 1,000 to <1,500 pg/mln = 1,332
- 1,500 to <3,000 pg/mln = 1,476
- ≥3,000 pg/mln = 725
- Outcome
- Composite of:
- Myocardial injury after noncardiac surgery
- Vascular death
- Follow-up
- 30 days
Methodological detailsRecruitment October 27, 2008 to October 30, 2013
- Recruitment October 27, 2008 to October 30, 2013
Main finding
As reported in the abstract
Each group vs <1,000 pg/mlAdjusted hazard ratio (95% CI)
1,000 to <1,500 pg/ml
1.93(1.50–2.48)
1,500 to <3,000 pg/ml
3.04(2.41–3.84)
≥3,000 pg/ml
4.8(3.76–6.14)
Observational data: associations, not effects.
Further findings
Preoperative GDF-15 concentration, whole cohort
- Median preoperative GDF-15 (IQR 880 to 2,132 pg/ml)
- 1,325
Cardiac risk classification improvement, GDF-15 added to Revised Cardiac Risk Index vs Revised Cardiac Risk Index alone
- Improvement in risk classification (301 per 1,000 patients)
- 30.1%
Additional risk classification beyond N-terminal-pro hormone brain natriuretic peptide plus Revised Cardiac Risk Index
- Additional risk classification (161 per 1,000 patients)
- 16.1%
Original publication
Association of Preoperative Growth Differentiation Factor-15 Concentrations and Postoperative Cardiovascular Events after Major Noncardiac Surgery. Anesthesiology. Published 11 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →