Perioperative medicine & outcomes
Role of the Perioperative Growth Differentiation Factor-15 Kinetics in Identifying Patients at High Risk for Postoperative Pulmonary Complications Following Thoracic Surgery
Main finding · Serum GDF-15 at end of surgeryResult — go to the resultHazard ratio 5.9 95% CI 1.73–20.09Authors' conclusion
In patients undergoing thoracic surgery, perioperative assessment of GDF-15 serum kinetics helps to stratify the postoperative risk of PPC.
Study context
- Population
- Consecutive adults undergoing non-cardiac thoracic surgery, university hospitalconsecutive
- Participants
- 101 adults
- Exposure
- Postoperative pulmonary complications (PPC) vs no PPC
- PPCn = 23
- Outcome
- PPC (composite:
- Pneumonia
- Severe respiratory failure
- Reintubation
- ARDS)
Methodological detailssingle-centre
- Single-centre
Main finding
Serum GDF-15 at end of surgery · End of surgery
Hazard ratio
5.9
95% CI 1.73–20.09
By group
GDF-15 increase >60% at end of surgery
HR 5.9 (95% CI 1.73–20.09)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Serum GDF-15 at 72 h after surgery · 72 hours after surgery — PPC vs No PPC
P < 0.001
Serum GDF-15 at 72 h after surgery
| HR (95% CI) | ||
|---|---|---|
| GDF-15 increase >68% at 72 hMultivariate Cox model; outcome PPC | 4.1 (1.36–12.62) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Role of the Perioperative Growth Differentiation Factor-15 Kinetics in Identifying Patients at High Risk for Postoperative Pulmonary Complications Following Thoracic Surgery. J Cardiothorac Vasc Anesth. Published 17 October 2025. doi:10.
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