Perioperative medicine & outcomes
Association between postinduction hypotension and postoperative mortality: a single-centre retrospective cohort study
Authors' conclusion
Despite limitations, including power and residual confounding, postoperative mortality was associated with IOH but not with PIH.
Study context
- Population
- Adults, ASA I–IV, noncardiac and nonobstetric surgery under GA, 2015–2021, Nagoya City University Hospital
- Exposure
- Postinduction hypotension (PIH) vs IOH
- Outcome
- 30-day postoperative mortality
- Follow-up
- 30 days
Methodological detailssingle-centre, multivariable logistic regression, propensity score matching and RUSBoost sensitivity analyses
- Single-centre
- Multivariable logistic regression
- Propensity score matching and RUSBoost sensitivity analyses
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)P value
PIH
1.03(0.93–1.13)
P = 0.60IOH
1.19(1.12–1.27)
P < 0.001- Overall 30-day mortality
- 0.4% (52/14,210)
Observational data: associations, not effects.
Secondary outcomes
90-day postoperative mortality
| aOR (95% CI) | P value | ||
|---|---|---|---|
| PIH | 1.01 (0.94–1.07) | P = 0.82 | |
| IOH | 1.12 (1.06–1.19) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
- 90-day postoperative mortality — Overall 90-day mortality
- 1.0% (138/13,334)
Incidence of hypotension
- PIH observed
- 82%
- IOH observed
- 84%
Sensitivity analyses
- Supported the association of IOH but not PIH with postoperative mortality
Original publication
Association between postinduction hypotension and postoperative mortality: a single-centre retrospective cohort study. Can J Anaesth. Published 21 November 2023. doi:10.
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