Perioperative medicine & outcomes

Association between Preoperative Blood Pressures and Postoperative Adverse Events

AnesthesiologyPublished Retrospective cohort study

Authors' conclusion

Preoperative blood pressures both less than and above a specific threshold were independently associated with a higher number of postoperative adverse events

Study context

Population
Adults having elective procedures requiring an inpatient stay, Vanderbilt University Medical Center, November 2017–July 2021
Participants
57,389 cases
Exposure
Day-of-surgery preoperative SBP and DBP vs reference values
Outcome
Number of postoperative adverse events (myocardial injury, stroke, AKI, mortality)
Follow-up
Within 30 days of surgery
Methodological detailsobservational, single-centre, multivariable ordinal logistic regression
  • Observational
  • Single-centre
  • Multivariable ordinal logistic regression

Main finding

As reported in the abstract

Number of postoperative adverse events
Adjusted odds ratio (95% CI)P value
SBP 173 mmHg vs SBP 143 mmHg
1.212(1.021–1.439)
P = 0.028
SBP 93 mmHg vs SBP 143 mmHg
1.339(1.211–1.479)
P < 0.001
DBP 46 mmHg vs DBP 86 mmHg
1.399(1.244–1.558)
P < 0.001
DBP 106 mmHg vs DBP 86 mmHg · CI as printed
aOR 1.294 (95% CI 1.003–1.17671); P = 0.048

Observational data: associations, not effects.

Further findings

Overall incidence of postoperative adverse events · within 30 days of surgery

Myocardial injury
3.4% (1,967 events)
Stroke
0.4% (223)
AKI
10.2% (5,871)
Mortality
2.1% (1,223)

Original publication

Association between Preoperative Blood Pressures and Postoperative Adverse Events. Anesthesiology. Published 1 April 2024. doi:10.1097/aln.0000000000004991

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