Association between preoperative vitamin D level and postoperative pain in patients undergoing breast cancer surgery: a prospective observational study
Authors' conclusion
Vitamin D deficiency is associated with a higher occurrence of moderate to severe postoperative pain and increased opioid consumption in patients undergoing unilateral modified radical mastectomy.
Study context
- Population
- American Society of Anesthesiologists (ASA) II–III female patients scheduled for elective unilateral modified radical mastectomy, Fayoum University Hospital, September 2024–April 2025
- Participants
- 184 patients
- Exposure
- Vitamin D-deficient vs vitamin D-sufficient
- Vitamin D-deficientn = 92
- Vitamin D-sufficientn = 92reference
- Outcome
- Moderate to severe postoperative pain (NRS >3)
- Follow-up
- 12 hours
Methodological detailssingle-centre, Baseline characteristics well balanced, small standardized mean differences for all variables
- Single-centre
- Baseline characteristics well balanced, small standardized mean differences for all variables
Main finding
As reported in the abstract
- Higher occurrence of moderate to severe pain at 12 hours in vitamin D-deficient patients
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Mean difference (µg) (95% CI) | |
|---|---|---|
| Intraoperative fentanyl consumption | 8.04 (3.21–12.88) | |
| −1001020Difference, µg (linear scale) |
| Outcome | Mean difference (mg) (95% CI) | |
|---|---|---|
| Postoperative tramadol consumption | 112.17 (101.44–122.91) | |
| −50050100150Difference, mg (linear scale) |
Moderate to severe pain (Numerical Rating Scale (NRS) >3) at any time within first 24 h (multivariable analysis)
- Vitamin D deficiency independently associated with moderate to severe postoperative pain, adjusted OR
- 3.12 (95% CI 1.58 to 6.13)
- Multivariable logistic regression
Original publication
Association between preoperative vitamin D level and postoperative pain in patients undergoing breast cancer surgery: a prospective observational study. Reg Anesth Pain Med. Published 19 May 2026. doi:10.
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