Impact of Genetic Variants on Postoperative Pain and Fentanyl Dose Requirement in Patients Undergoing Major Breast Surgery: A Candidate Gene Association Study
Main finding · 24-hour postoperative fentanyl requirement (rs1799971)Result — go to the resultGM ratio 1.91 95% CI 1.071–1.327Authors' conclusion
The SNP opioid receptor mu-1 ( OPRM1 ) (rs1799971) was associated with higher postoperative fentanyl requirement in South Indian patients undergoing major breast surgery.
Study context
- Population
- South Indian women, aged 18–70 years, American Society of Anesthesiologists (ASA) I–III, undergoing major breast surgery under GA with standardized IV fentanyl patient-controlled analgesic (PCA)
- Participants
- 257 women
- Comparison
- Carriers vs non-carriers of 10 candidate single nucleotide polymorphisms (SNPs) in 9 genes
- Outcome
- Postoperative fentanyl dose (PCA)
- Follow-up
- 24 hours
Main finding
As reported in the abstract
24-hour postoperative fentanyl requirement (rs1799971)
Geometric mean (GM) ratio
1.91
95% CI 1.071–1.327
By group
Secondary outcomes
Median
| Outcome | G/G | A/A + A/G | GM ratio (95% CI) |
|---|---|---|---|
| 24-hour pain scores (rs4680, COMT) | 31 (range 30–38) | 34 (range 30–38) | 1.059 (1.018–1.101) |
| 24-hour pain scores (rs1045642, ABCB1) | 30 (range 30–34) | 34 (range 30–38) | 0.936 (0.889–0.987) |
| Time for first analgesic (rs734784, KCNS1)C/C vs T/T + C/T | 0.902 (0.837–0.972) |
- Time for first analgesic (rs734784, KCNS1): C/C median 240 (range 180–270) minutes
- Time for first analgesic (rs734784, KCNS1): T/T + C/T median 240 (range 210–270) minutes
Original publication
Impact of Genetic Variants on Postoperative Pain and Fentanyl Dose Requirement in Patients Undergoing Major Breast Surgery: A Candidate Gene Association Study. Anesth Analg. Published 20 December 2022. doi:10.
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