ICU sedation, delirium & recovery
The Association Between Prepandemic ICU Performance and Mortality Variation in COVID-19: A Multicenter Cohort Study of 35,619 Critically Ill Patients
Main finding · In-hospital mortality by baseline ICU performanceResult — go to the resultOdds ratio 2.30 95% CI 1.45–3.62Authors' conclusion
ICUs caring for patients with COVID-19 presented substantial variation in risk-adjusted mortality. ICUs with better baseline (prepandemic) performance showed reduced mortality and less variability.
Study context
- Population
- Adults with RT-PCR-confirmed COVID-19 admitted to 156 ICUs in 35 hospitals in Brazil, February 16, 2020, to December 31, 2021
- Participants
- 35,619 adults · 156 ICUs · 35 hospitals
- Exposure
- Baseline (prepandemic) ICU performance groups: least efficient and underachieving vs most efficient
- Outcome
- In-hospital mortality (risk-adjusted)
Methodological detailsmulticentre, multivariable mixed regression model, variable life-adjusted display (VLAD)
- Multicentre
- Multivariable mixed regression model
- Variable life-adjusted display (VLAD)
Main finding
As reported in the abstract
In-hospital mortality by baseline ICU performance
Odds ratio
2.30
95% CI 1.45–3.62
Baseline (prepandemic) ICU performance groups: least efficient and underachieving vs most efficient
OR 2.30 (95% CI 1.45–3.62)
- Weeks with VLAD higher than overall median: most efficient
- 18%
- Weeks with VLAD higher than overall median: underachieving
- 62%
- Weeks with VLAD higher than overall median: least efficient
- 84%
Observational data: associations, not effects.
Further findings
Overall in-hospital mortality
- All patients
- 13%
- Patients receiving invasive mechanical ventilation
- 54%
- Range of adjusted in-hospital mortality across ICUs
- 3.6% to 63.2%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Association Between Prepandemic ICU Performance and Mortality Variation in COVID-19: A Multicenter Cohort Study of 35,619 Critically Ill Patients. Chest. Published 13 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →