Perioperative medicine & outcomes
Association between prolonged corticosteroids use in COVID-19 and increased mortality in hospitalized patients: a retrospective study with inverse probability of treatment weighting analysis
Authors' conclusion
Prolonged course of treatment with corticosteroids in hospitalized patients with COVID-19 was associated with higher mortality.
Study context
- Population
- Adults with COVID-19 (positive SARS-CoV-2 test) hospitalised for more than 10 days
- Participants
- 1,539 adults
- Exposure
- Prolonged-course vs short-course corticosteroids
- Prolonged-coursen = 1,127
- Outcome
- In-hospital mortality
Methodological detailsinverse probability of treatment weighting
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
P < 0.001
- Inverse probability treatment weighting (IPTW): prolonged corticosteroid use significantly increased mortality, RR
- 1.52 (95% CI 1.24-1.89)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | RR (95% CI) | |
|---|---|---|
| Mortality by duration of corticosteroid use (cubic spline) · 30 days of useHighest risk, at 30 days of use | 1.50 (1.21–1.78) | |
| 0.512Relative risk (log scale) |
Mortality by duration of corticosteroid use (cubic spline) · 30 days of use
- Inverted U-shaped curve for mortality
Original publication
Association between prolonged corticosteroids use in COVID-19 and increased mortality in hospitalized patients: a retrospective study with inverse probability of treatment weighting analysis. Crit Care. Published 15 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →