Respiratory failure & ventilation
Association between respiratory-related cortical activation and weaning from mechanical ventilation: a physiological study
Authors' conclusion
The demonstration of an association between increased respiratory-related cortical activation and failure of the weaning trial is a physiological marker of interest for better phenotyping of patients ready for weaning.
Study context
- Population
- Mechanically ventilated patients meeting weaning criteria17 (27%) failed spontaneous breathing trial (SBT)
- Participants
- 62 participants
- Exposure
- SBT failure vs SBT success
- SBT failuren = 17
- Outcome
- PIP amplitude (EEG) under mechanical ventilation and during the first 15 min of the SBT, by SBT outcome
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
PIP amplitude change between mechanical ventilation and SBT
SBT failure
+ 1.7
IQR 1.2–2.1 · µV
SBT success
−0.5
IQR −1.8–0.1
P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | SBT failure | SBT successMedian | P value |
|---|---|---|---|
| PIP amplitude under mechanical ventilation | median 0.6 (IQR 0–1.3) µV | 1.9 (IQR 1.2–2.9) | P < 0.0001 |
| PIP amplitude at the beginning of the SBT | median 2.1 (IQR 1.7–2.9) µV | 1.2 (IQR 0.5–2.0) | P < 0.005 |
PIP increase >0.43 µV for predicting SBT failure
- Sensitivity
- 100%
- Specificity
- 87%
Original publication
Association between respiratory-related cortical activation and weaning from mechanical ventilation: a physiological study. Crit Care. Published 3 November 2025. doi:10.
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