Association Between Systemic Anticoagulation and Outcomes in Patients With Acute Respiratory Distress Syndrome Receiving Venovenous Extracorporeal Membrane Oxygenation: Insights From a Multicenter Propensity-Weighted Study
Authors' conclusion
Systemic anticoagulation was not associated with short-term survival.
Study context
- Population
- Adults receiving VV-ECMO for Acute Respiratory Distress Syndrome (ARDS) in 24 ICUs in Japan
- Participants
- 695 adults · 24 ICUs
- Exposure
- Systemic anticoagulation vs no anticoagulation during VV-ECMO
- Outcome
- 28-day survival
- Follow-up
- 28 days
Methodological detailsmulticentre, propensity score-overlap-weighted analysis, sensitivity analysis using inverse probability of treatment weighting
- Multicentre
- Propensity score-overlap-weighted analysis
- Sensitivity analysis using inverse probability of treatment weighting
Main finding
As reported in the abstract
P = 0.50
Observational data: associations, not effects.
Further findings
Average activated partial thromboplastin time during ECMO · significantly higher in the anticoagulation group
P < 0.01
60-day survival, ECMO duration, circuit exchanges, transfusion volumes
- Comparable between groups
Sensitivity analysis (inverse probability of treatment weighting)
- Findings remained consistent
Safety
Bleeding complications
- Comparable between groups
Original publication
Association Between Systemic Anticoagulation and Outcomes in Patients With Acute Respiratory Distress Syndrome Receiving Venovenous Extracorporeal Membrane Oxygenation: Insights From a Multicenter Propensity-Weighted Study. Crit Care Med. Published 19 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →